The activation of CB1 and CB2 inhibits the development of intracellular cAMP, for this reason leading to a tremendous reduction in the excitatory outcome within the neurons [88,89]. Moreover, the activation of CB2 can even more protect against the mast cell degranulation and the discharge of professional-inflammatory mediators, earning the reductio
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Research should consist of people with bigger pain severity (increased than 50/one hundred with a one hundred‐point visual analogue scale) at baseline. People with moderate‐moderate pain should continue to be involved, but It will be recommended to separate the final results for analysis, guaranteeing the review is sufficiently run to permit th